Route of administration

The oral route is generally the most convenient and costs the least.

However, some drugs can cause gastrointestinal tract irritation.

For drugs that come in delayed-release or time-release formulations, breaking the tablets or capsules can lead to more rapid delivery of the drug than intended.

The oral route is limited to formulations containing small molecules only while biopharmaceuticals (usually proteins) would be digested in the stomach and thereby become ineffective. Biopharmaceuticals have to be given by injection or infusion. However, recent research (2018) found an organic ionic liquid suitable for oral insulin delivery (a biopharmaceutical) into the bloodstream.

Oral administration is often denoted “PO” from “per os”, the Latin for “by mouth”.

The bioavailability of oral administration is affected by the amount of drug that is absorbed across the intestinal epithelium and first-pass metabolism.

  • oral.txt
  • Last modified: 2021/02/15 18:51
  • by administrador