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os_odontoideum [2019/08/18 18:06]
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administrador [Os odontoideum]
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 +====== Os odontoideum ======
 +
 +{{ ::​os-odontoideum.jpg|}}
 +
 +Hypoplasia of the [[Odontoid process]] associated with an independent oval ossicle, with smooth margins widely separated from C2 and well above the superior facets of the axis, is termed "os odontoideum"​
 +
 +Carlo Giacomini was the first to describe the os odontoideum in [[1886]] and to suggest that the presence of an incompetent [[odontoid process]] may alter the motion of [[craniovertebral junction]], anticipating the concept of [[spine instability]]
 +((Perrini P, Montemurro N, Iannelli A. The contribution of Carlo Giacomini
 +(1840-1898):​ the limbus Giacomini and beyond. Neurosurgery. 2013
 +Mar;​72(3):​475-81;​ discussion 481-2. doi: 10.1227/​NEU.0b013e31827fcda3. PubMed
 +PMID: 23208067.)).
 +
 +It is a rare anomaly.
 +
 +
 +
 +
 +
 +
 +====Pathogenesis====
 +Controversial pathogenesis and poorly understood natural history.
 +
 +One theory states that the apex of the odontoid separates from the body because of a fracture. The intact alar and apical ligaments pull the fractured segment superiorly. The independent vascular supply of the apex allows the fractured bone to remain viable and remodel into the smooth, corticated bone characteristic of an os odontoideum. However, there are no publications with direct radiographic evidence supporting the theory
 +((White IK, Mansfield KJ, Fulkerson DH. Sequential imaging demonstrating os
 +odontoideum formation after a fracture through the apical odontoid epiphysis:
 +case report and review of the literature. Childs Nerv Syst. 2013
 +Nov;​29(11):​2111-5. doi: 10.1007/​s00381-013-2132-6. Epub 2013 May 7. PubMed PMID: 
 +23649960.)).
 +
 +Hypertrophy of the dens and os odontoideum are rare conditions causing cervical myelopathy reported either singly or in combination. Hypertrophy of the posterior arch of atlas in the absence of any ring hypoplasia as a cause of cervical myelopathy has reported
 +((Kasliwal MK, Traynelis VC. Hypertrophic posterior arch of atlas causing
 +cervical myelopathy. Asian Spine J. 2012 Dec;​6(4):​284-6. doi:
 +10.4184/​asj.2012.6.4.284. Epub 2012 Dec 14. PubMed PMID: 23275813; PubMed Central
 +PMCID: PMC3530704.)).
 +
 +====Clinical==== ​
 +The neurological manifestations arise from bulbospinal compression both at rest and during motion, due to the craniovertebral junction (CVJ) instability itself. ​
 +
 +Ondine'​s curse or central hypoventilation syndrome
 +((Campbell E, Brown J. Case report of os odontoideum causing Ondine'​s curse. Br 
 +J Neurosurg. 2013 Dec;​27(6):​836-7. doi: 10.3109/​02688697.2013.795520. Epub 2013
 +May 14. PubMed PMID: 23672469.)).
 +
 +[[http://​www.imagenologia.cl/​rad92/​caso%20radiolzunino2.html|Images]]
 +
 +====Treatment==== ​
 +There is a role for conservative treatment of an asymptomatic incidentally found, radiologically stable, and noncompressive os odontoideum,​ however surgery has a definite role in symptomatic cases
 +((Karmakar PS, Karmakar PS, Mitra R, Basu S, Ghosh A. Sudden onset quadriparesis
 +after minor injury to neck in a male with OS odontoideum. J Assoc Physicians
 +India. 2013 Feb;​61(2):​138-9. PubMed PMID: 24471254.)).
 +
 +Consequently,​ the surgical management of os odontoideum should aim at achieving both neural decompression and stabilization of the craniovertebral junction (CVJ)
 +((Visocchi M, Di Rocco C. Os odontoideum syndrome: pathogenesis,​ clinical
 +patterns and indication for surgical strategies in childhood. Adv Tech Stand
 +Neurosurg. 2014;​40:​273-93. doi: 10.1007/​978-3-319-01065-6_9. PubMed PMID:
 +24265050.)).
 +
 +===== Case series =====
 +A total of 119 patients who underwent atlantoaxial fixation for instability were identified between January 1998 and January 2014. Inclusion criteria included age more than 21 years and diagnosis of OO and non-OO. There were 22 OO patients, and 20 non-OO patients. Measuring the Oc-C1 Cobb angle, C1-2 Cobb angle, C2-7 Cobb angle, and C2-7 sagittal vertical axis (SVA) was assessed. Clinical outcome was assessment of suboccipital pain was determined using a visual analogue scale (VAS), and Japanese Orthopedic Association (JOA) scores were obtained in all patients pre- and postoperatively.
 +
 +The preoperative C1-2 angle in the OO group (26.02°±10.53°) was significantly higher than the non-OO group (p=0.04). After C1-2 fixation, the OO group had significantly higher kyphotic change in the C1-2 angle (ΔC1-2) (3.2°±7.3° [OO] vs. -1.46°±7.21° [non-OO]) (p=0.04), and higher decrease in postoperative C2-7 SVA (ΔC2-7 SVA) (5.64±11.56 mm [OO] vs. -0.51± 6.57 mm [non-OO]) (p=0.04). Both groups showed improvements in the health related quality of life (HRQOL) after surgery based on the VAS and JOA score (p<​0.001).
 +
 +After fixation, kyphotic angular change in atlantoaxial joint and decrease C2-7 SVA were marked in the OO group. Both the OO and non-OO groups improved in neurological function and outcome after surgery
 +((Yudoyono F, Kang J, Ha Y. Comparison of Cervical Alignment and Clinical
 +Outcomes in Patients with Os Odontoideum versus Non-Os Odontoideum after
 +Atlantoaxial Fixation. Korean J Spine. 2017 Dec;​14(4):​143-147. doi:
 +10.14245/​kjs.2017.14.4.143. Epub 2017 Dec 31. PubMed PMID: 29301174.
 +)).
  
os_odontoideum.txt · Last modified: 2019/08/18 18:06 by administrador