parkinsonism

Parkinsonism

Parkinsonism is a clinical syndrome characterized by tremor, bradykinesia, rigidity, and postural instability.

Parkinsonism may be primary or secondary to other conditions. All result from a relative loss of dopamine mediated inhibition of the effects of acetylcholine in the basal ganglia.

Ischemic (lacunes in basal ganglia): produces so-called arteriosclerotic parkinsonism AKA vascular parkinsonism: “lower-half” parkinsonism (gait disturbance predominates 1)).

Also causes pseudobulbar deficits, emotional lability. Tremor is rare

It is found in Parkinson's disease (PD)—after which it is named—dementia with Lewy bodies (DLB), and Parkinson's disease dementia (PDD), and many other conditions. A wide range of causes may lead to this set of symptoms, including neurodegenerative conditions, drugs, toxins, metabolic diseases, and neurological conditions other than PD.

see Parkinson's disease

see Secondary parkinsonism.


1)
Lang AE, Lozano AM. Parkinson's Disease. First of Two Parts. N Engl J Med. 1998; 339:1044–1053
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