Primary central nervous system lymphoma classification

The majority of primary central nervous system (CNS) lymphomas are diffuse large B-cell lymphomas (DLBCLs) and anaplastic large-cell lymphoma (ALCL) is a type of T-cell tumor that is rare in the CNS.

Similar to the findings for systemic ALCL, anaplastic lymphoma kinase (ALK)-positivity, age <40 years and chemotherapy are associated with long-term survival for ALCL of the CNS. Chemoradiotherapy including methotrexate is recommended for ALCL and the possibility of treatment with chemotherapy alone for ALK-positive ALCL is currently under consideration 1).

see Intraventricular lymphoma

see Spinal cord lymphoma

Isolated primary central nervous system lymphoma arising from anterior visual pathway is very rare.

Primary central nervous system ALK-positive anaplastic large cell lymphoma

Nomura M, Narita Y, Miyakita Y, Ohno M, Fukushima S, Maruyama T, Muragaki Y, Shibui S. Clinical presentation of anaplastic large-cell lymphoma in the central nervous system. Mol Clin Oncol. 2013 Jul;1(4):655-660. Epub 2013 Apr 30. PubMed PMID: 24649224; PubMed Central PMCID: PMC3915681.
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  • Last modified: 2021/09/27 15:51
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