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Prothrombin complex concentrate (PCC)


The administration of Prothrombin complex concentrate (PCC) facilitates emergency spinal surgery in anticoagulated patients who present with acute spinal pathology requiring urgent neurosurgical decompression.


The risk of PCC-associated thromboembolic events seems to be low and justifies the use of PCC in order to avoid permanent disablement resulting from delayed surgery or non-operation 1).

A 4-factor prothrombin complex concentrate (4F-PCC), containing therapeutic doses of vitamin K-dependent coagulation factors, was recently licensed in the United States for reversal of vitamin K antagonist therapy. However, given the emergence of several oral anticoagulants for which there are no specific reversal agents, and the existence of many other complex bleeding disorders, it is likely that clinicians will seek to use 4F-PCCs for any number of off-label indications 2).

Case series

A prospective, observational study of all patients undergoing coagulopathy reversal for intracranial hemorrhage from April 2013 to December 2013 at a single, tertiary care center was undertaken. Thirty three patients underwent emergent reversal of coagulopathy using either FFP or PCC at the discretion of the treating physician. Intracranial hemorrhage included subdural hematoma, intraparenchymal hematoma, and subarachnoid hemorrhage. FFP was used in 28 patients and PCC was used in five patients. International normalized ratio at presentation was similar between groups (FFP 2.9, PCC 3.1, p=0.89). The time to reversal was significantly shorter in the PCC group (FFP 256minutes, PCC 65minutes, p<0.05). When operations were performed, the time delay to perform operations was also significantly shorter in the PCC group (FFP 307minutes, PCC 159minutes, p<0.05). In this preliminary experience, PCC appears to provide a rapid reversal of coagulopathy. Normalization of coagulation parameters may prevent further intracranial hematoma expansion and facilitate rapid surgical evacuation, thereby improving neurological outcomes 3).

Beynon C, Potzy A, Unterberg AW, Sakowitz OW. Prothrombin complex concentrate facilitates emergency spinal surgery in anticoagulated patients. Acta Neurochir (Wien). 2014 Apr;156(4):741-7. doi: 10.1007/s00701-014-2032-x. Epub 2014 Feb 26. PubMed PMID: 24570188.
Unold D, Tormey CA. Clinical Applications of 4-Factor Prothrombin Complex Concentrate: A Practical Pathologist's Perspective. Arch Pathol Lab Med. 2015 Dec;139(12):1568-75. doi: 10.5858/arpa.2014-0366-RS. PubMed PMID: 26619030.
Yanamadala V, Walcott BP, Fecci PE, Rozman P, Kumar JI, Nahed BV, Swearingen B. Reversal of warfarin associated coagulopathy with 4-factor prothrombin complex concentrate in traumatic brain injury and intracranial hemorrhage. J Clin Neurosci. 2014 Jun 18. pii: S0967-5868(14)00248-3. doi: 10.1016/j.jocn.2014.05.001. [Epub ahead of print] PubMed PMID: 24953825.
prothrombin_complex_concentrate.txt · Last modified: 2016/01/05 01:27 (external edit)