User Tools

Site Tools


Proton beam radiotherapy

Proton radiotherapy (PRT) reduces the volume of normal tissue receiving radiation dose, which may lead to better neurocognitive outcomes. We examined change in neurocognitive scores over time in pediatric brain tumor patients treated with proton craniospinal irradiation (CSI), proton focal RT, or surgery only.

METHODS: Patients received annual neurocognitive evaluations for up to 6 years. We examined Full Scale IQ (FSIQ), Verbal Comprehension (VCI), Perceptual Reasoning (PRI), Working Memory (WMI), and Processing Speed Index (PSI) scores. General linear mixed models examined change in scores over time by treatment group, adjusting for significant covariates.

RESULTS: Scores from 93 patients treated between 2012-2017 (22 proton CSI, 31 proton focal, and 40 surgery only) were examined. Treatment groups were similar on gender (51.6% male), age at treatment (median=9.7 years), and length of follow-up (median=2.9 years). The surgery only group had proportionately more gliomas (p<0.001), and the proton CSI group had more infratentorial tumors (p=0.001) and higher total RT dose (p=0.004). The proton focal and surgery only groups exhibited stable neurocognitive scores over time across all indexes (all p>0.05). In the proton CSI group, WMI, PSI, and FSIQ scores declined significantly (p=0.036, 0.004, and 0.017, respectively), while VCI and PRI scores were stable (all p>0.05).

CONCLUSIONS: Focal PRT was associated with stable neurocognitive functioning into survivorship. Outcomes were similar whether patients received focal PRT or no radiotherapy, even in neurocognitive domains known to be particularly radiosensitive. Proton CSI emerged as a neurocognitive risk factor, consistent with photon outcomes research 1).

Proton therapy (PRT) is an advanced radiotherapy (RT) modality with a unique dose-deposition pattern that allows for treatment of a target volume with reduced scatter dose delivered to normal tissues compared with conventional photon RT and is now increasingly utilized in children with the hope of mitigating radiation-induced late effects. A article reviews the current literature evaluating the use of PRT in benign and low-grade pediatric central nervous system tumors such as low grade glioma, craniopharyngioma, and ependymoma. Multiple dosimetric studies support the use of PRT by demonstrating the ability of PRT to better spare critical structures important for cognitive development, endocrine function, and hearing preservation and to reduce the total body dose associated with second malignancy risk. Early clinical data demonstrate that PRT is well tolerated with rates of local tumor control comparable to conventional photon RT series, and long-term clinical data are awaited 2).

Kahalley LS, Ris MD, Mahajan A, Okcu MF, Chintagumpala M, Paulino AC, Whitehead WE, Minard CG, Stancel HH, Orobio J, Xue JJ, Warren EA, Grosshans DR. Prospective, Longitudinal Comparison of Neurocognitive Change in Pediatric Brain Tumor Patients Treated with Proton Radiotherapy versus Surgery Only. Neuro Oncol. 2019 Feb 7. doi: 10.1093/neuonc/noz041. [Epub ahead of print] PubMed PMID: 30753584.
Eaton BR, Yock T. The use of proton therapy in the treatment of benign or low-grade pediatric brain tumors. Cancer J. 2014 Nov-Dec;20(6):403-8. doi: 10.1097/PPO.0000000000000079. PubMed PMID: 25415686.
proton_beam_radiotherapy.txt · Last modified: 2019/02/14 01:00 (external edit)