Radiotherapy

Radiation therapy, radiotherapy, or radiation oncology, often abbreviated RT, RTx, or XRT, is the medical use of ionizing radiation, generally as part of cancer treatment to control or kill malignant cells. Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body. It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor (for example, early stages of breast cancer). Radiation therapy is synergistic with chemotherapy and has been used before, during, and after chemotherapy in susceptible cancers.

3D based radiotherapy

Intraoperative radiotherapy

Fractionated radiotherapy

Conformal radiation therapy

External beam radiotherapy

Stereotactic radiotherapy

Stereotactic body radiotherapy

Gamma Knife radiosurgery

Proton beam radiotherapy.

Whole brain radiotherapy

The last major advance in glioblastoma treatment was the introduction of temozolomide in 1999.

Concomitant radiotherapy + temozolamide is more effective and improves the overall survival and progression free survival in patients with newly diagnosed glioblastoma.

Steroids are very commonly administered concurrently with temozolomide and radiotherapy after the initial surgical resection of glioblastoma (Glioblastoma) to control neurological morbidity. Although the potent anti-inflammatory effect of steroids is well documented to ameliorate vasogenic edema in these tumors, the deleterious effects of steroids on the efficacy of alkylating agents or radiotherapy have been a matter of debate ^{1) 2) 3) 4)}.