Renal cell carcinoma

see Brain metastases from renal cell carcinoma.

Renal cell carcinoma (RCC) frequently metastasizes to the spine, and the prognosis can be quite variable.


Surgical removal of the tumor with spinal reconstruction has been a mainstay of palliative treatment.


The ability to predict prognosis is valuable when determining the role and magnitude of surgical intervention in cancer patients.

Tatsui et al., identified several factors influencing survival after spine surgery for metastatic spinal RCC, including grade of the original nephrectomy specimen, activity of the systemic disease, and neurological status at the time of surgery. These clinical features may help to identify patients who may benefit from aggressive surgical intervention 1).

Spinal nerve root metastasis of renal cell carcinoma is a rare occurrence. In addition to treatment of the primary lesion, surgical resection of the nerve root metastasis, occasionally with sacrifice of the involved nerve, is the accepted standard of treatment. Resection often resolves presenting motor and pain symptoms due to relief of neural compression.

Tatsui CE, Suki D, Rao G, Kim SS, Salaskar A, Hatiboglu MA, Gokaslan ZL, McCutcheon IE, Rhines LD. Factors affecting survival in 267 consecutive patients undergoing surgery for spinal metastasis from renal cell carcinoma. J Neurosurg Spine. 2014 Jan;20(1):108-16. doi: 10.3171/2013.9.SPINE13158. Epub 2013 Nov 8. PubMed PMID: 24206037.
  • renal_cell_carcinoma.txt
  • Last modified: 2020/03/29 12:09
  • by administrador