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romo1 [2020/01/17 22:25]
administrador
romo1 [2020/01/17 22:36] (current)
administrador
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 [[Reactive oxygen species]] ([[ROS]]) modulator 1 (Romo1) is a mitochondrial membrane protein that is essential for the regulation of mitochondrial ROS production and [[redox]] sensing. Although the physiological functions of Romo1 have been studied for the past few years, the role of Romo1 in [[cancer]] remained unclear.  [[Reactive oxygen species]] ([[ROS]]) modulator 1 (Romo1) is a mitochondrial membrane protein that is essential for the regulation of mitochondrial ROS production and [[redox]] sensing. Although the physiological functions of Romo1 have been studied for the past few years, the role of Romo1 in [[cancer]] remained unclear. 
  
-In a study, Sun et al. from [[Yancheng]] found that the high expression of Romo1 is associated with the poor [[prognosis]] of   - glioblastoma patients. Further study revealed that Romo1 is highly expressed in [[macrophage]]s, indicating that the overexpression of Romo1 may participate in the function of macrophages and contribute to the progression of glioblastoma. Through the glioblastoma mouse model, they found that the overexpression of Romo1 in [[bone marrow]] cells significantly inhibited the immune response within tumor [[microenvironment]] and that the overexpression of Romo1 resulted in the M2 polarization of bone marrow-derived macrophages (BMDMs) through mTORC1 signaling pathway. In addition, the inhibition of Romo1 combining with anti-PD-1 immunotherapy significantly improved the survival outcome of glioblastoma in mouse model. Collectively, ther study highlights the important role of Romo1 in immune response especially the function of macrophages and implicates it as a potential target of [[immunotherapy]] for glioblastoma+In a study, Sun et al. from [[Yancheng]] found that the high expression of Romo1 is associated with the poor [[prognosis]] of   - glioblastoma patients. Further study revealed that Romo1 is highly expressed in [[macrophage]]s, indicating that the overexpression of Romo1 may participate in the function of macrophages and contribute to the progression of glioblastoma. Through the glioblastoma mouse model, they found that the overexpression of Romo1 in [[bone marrow]] cells significantly inhibited the immune response within tumor [[microenvironment]] and that the overexpression of Romo1 resulted in the M2 polarization of bone marrow-derived macrophages (BMDMs) through mTORC1 signaling pathway. In addition, the inhibition of Romo1 combining with anti-PD-1 immunotherapy significantly improved the survival outcome of glioblastoma in mouse model. Collectively, ther study highlights the important role of Romo1 in immune response especially the function of macrophages and implicates it as a potential target of [[glioblastoma immunotherapy]] 
 ((Sun G, Cao Y, Qian C, Wan Z, Zhu J, Guo J, Shi L. Romo1 is involved in the ((Sun G, Cao Y, Qian C, Wan Z, Zhu J, Guo J, Shi L. Romo1 is involved in the
 immune response of glioblastoma by regulating the function of macrophages. Aging  immune response of glioblastoma by regulating the function of macrophages. Aging 
romo1.txt ยท Last modified: 2020/01/17 22:36 by administrador