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--- severe_acute_respiratory_syndrome_coronavirus_2 [2020/07/09 12:56]
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+++ severe_acute_respiratory_syndrome_coronavirus_2 [2020/10/23 17:23]
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 ====== Severe acute respiratory syndrome coronavirus 2 ======
-[[Severe acute respiratory syndrome]] coronavirus 2 ([[SARS]]-[[CoV-2]]) is the infectious agent responsible for [[coronavirus]] disease 2019 ([[COVID-19]]). Respiratory and gastrointestinal manifestations of SARS-CoV-2 are well described, less defined is the clinical neurological spectrum of COVID-19.
+[[Severe acute respiratory syndrome]] coronavirus 2 ([[SARS]]-[[CoV-2]]) is the infectious agent responsible for [[coronavirus]] disease 2019 ([[COVID-19]]).
-Agosti et al. reported a case of COVID-19 patient with acute monophasic [[Guillain-Barré syndrome]] (GBS), and a literature review on the SARS-CoV-2 and GBS etiological correlation.
-Case description: A 68 years-old man presented to the emergency department with symptoms of acute progressive symmetric ascending flaccid tetraparesis. Oropharyngeal swab for SARS-CoV-2 tested positive. Neurological examination showed bifacial nerve palsy and distal muscular weakness of lower limbs. The cerebrospinal fluid assessment showed an albuminocytologic dissociation. Electrophysiological studies showed delayed distal latencies and absent F waves in early course. A diagnosis of Acute Inflammatory Demyelinating Polyradiculoneuropathy (AIDP) subtype of GBS was then made.
-Neurological manifestations of COVID-19 are still under study. The case we described of GBS in COVID-19 patient adds to those already reported in the [[literature]], in support of SARS-CoV-2 triggers GBS. COVID-19 associated neurological clinic should probably be seen not as a corollary of classic respiratory and gastrointestinal symptoms, but as SARS-CoV-2-related standalone clinical entities. To date, it is essential for all Specialists, clinicians, and surgeons, to direct attention towards the study of this [[virus]], to better clarify the spectrum of its neurological manifestations
-((Agosti E, Giorgianni A, D'Amore F, Vinacci G, Balbi S, Locatelli D. Is Guillain-Barrè syndrome triggered by SARS-CoV-2? Case report and literature review [published online ahead of print, 2020 Jul 9]. Neurol Sci. 2020;10.1007/s10072-020-04553-9. doi:10.1007/s10072-020-04553-9)).