small-cell_lung_cancer

Small-cell lung cancer

Small cell lung cancer is a neuroendocrine tumor.

It is sometimes called “oat cell carcinoma” due to the flat cell shape and scanty cytoplasm.

see Small cell lung cancer intracranial metastases.

Small cell lung cancer (SCLC) is a life-threatening disease, typically caused by cigarette smoking. It is almost exclusively seen in current or former smokers. SCLC represents approximately 13–18% of all lung cancers with a varying incidence in different countries 1)

95 % arise in proximal airways, usually in mainstem or lobar brochii. Tipically younger (27-66 years) than other lung cancer. Strongly associated with cigarrete smoking

Although SCLC compromises only 20 % of primary lung cancers, it is more likely to produce cerebral metastases than other brochogenic cell types (brain metastases are found in 80 % of patients who survive 2 yrs after diagnosis SCLC) 2).

A recommendation to use TNM International Union Against Cancer (UICC) staging system for all SCLC cases was regularly accepted 3) 4) 5).

However, a simple two-stage system developed by the Veteran’s Administration Lung Cancer Study Group as limited (stage) disease (LD) or extensive (stage) disease (ED) was more frequently used in clinical practice 6).

Patients with limited disease have the involvement restricted to one hemithorax that can be encompassed within a tolerable radiation field. Extensive disease is defined as disease beyond one hemithorax and may include malignant pleural or pericardial effusion or haematogenous metastases.

see Small cell lung cancer treatment.

see Small cell lung cancer outcome.


1)
Wahbah M, Boroumand N, Castro C, El-Zeky F, Eltorky M. Changing trends in the distribution of the histologic types of lung cancer: a review of 4,439 cases. Ann Diagn Pathol. 2007;11:89–96.
2)
Nugent JL, Bunn PA Jr, Matthews MJ, Ihde DC, Cohen MH, Gazdar A, Minna JD. CNS metastases in small cell bronchogenic carcinoma: increasing frequency and changing pattern with lengthening survival. Cancer. 1979 Nov;44(5):1885-93. PubMed PMID: 227582.
3)
UICC International Union Against Cancer . Lung. In: Sobin LH, Gospodarowicz MK, Wittekind Ch, editors. TNM classification of malignant tumours. 7th edition. Chichester: Wiley-Blackwell; 2009. pp. 138–46.
4)
Debevec L, Jerič T, Kovač V, Sok M, Bitenc M. The progress in routine management of lung cancer patients. A comparative analysis of an institution in 1996 and 2006. Radiol Oncol. 2009;43:47–53.
5)
Vallières E, Shepherd FA, Crowley J, Van Houtte P, Postmus PE, Carney D, et al. International Association for the Study of Lung Cancer International Staging Committee and Participating Institutions The IASLC Lung Cancer Staging Project: proposals regarding the relevance of TNM in the pathologic staging of small cell lung cancer in the forthcoming (seventh) edition of the TNM classification for lung cancer. J Thorac Oncol. 2009;4:1049–59.
6)
Micke P, Faldum A, Metz T, Beeha K, Bittingerc F, Hengstlerd J, et al. Staging small cell lung cancer: Veterans Administration Lung Study Group versus International Association for the Study of Lung Cancer - what limits limited disease? Lung Cancer. 2002;37:271–6.
  • small-cell_lung_cancer.txt
  • Last modified: 2021/05/09 10:23
  • by administrador