Frame based stereotactic biopsy (FSB) remains the 'gold standard' for obtaining diagnostic samples of intracranial lesions to guide therapy. Nevertheless, diagnostic yield is highly variable.
The diagnostic yield from contemporary FSB is high and is dependent predominantly on lesion size. 1).
They have limitations with regard to flexibility and patient comfort because of the bulky head ring attached to the patient.
The stereotactic biopsy with advanced image guidance represents a safe, reliable and minimally invasive method for pathological diagnosis of intracranial lesions. Moreover, the developments of biochemical imaging gives a new concept to the stereotactic biopsy 2).
Stereotactic biopsy indications:
c) multiple small lesions (e.g. in some AIDS patients)