Temozolomide desensitization
There are minimal reports of temozolomide-induced DRESS syndrome. The diagnosis can be life-threatening, which makes the glioblastoma treatment with no alternative treatment option challenging. The use of temozolomide desensitization has been proposed for the management of severe adverse cutaneous drug reactions 1).
1)
Ambur A, Ambur L, Khan L, Nathoo R. Drug-induced hypersensitivity syndrome following temozolimide for glioblastoma multiforme and the role of desensitization therapy. J Oncol Pharm Pract. 2022 Apr;28(3):733-735. doi: 10.1177/10781552211062569. Epub 2021 Nov 26. PMID: 34825610.