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The Clot Lysis: Evaluating Accelerated Resolution of IVH trial examined whether irrigating the ventricular system with alteplase improved functional outcomes in patients with small intracerebral hemorrhage (ICH) and large intraventricular hemorrhage (IVH).

Poor outcomes were associated with mass-related obstruction of the third ventricle from thalamic ICH in alteplase-treated patients and from IVH in saline-treated patients. Once the ventricular system is cleared with alteplase, obstruction of cerebral spinal fluid flow from thalamic hemorrhage might become important in functional recovery 1).

Ullman NL, Tahsili-Fahadan P, Thompson CB, Ziai WC, Hanley DF. Third Ventricle Obstruction by Thalamic Intracerebral Hemorrhage Predicts Poor Functional Outcome Among Patients Treated with Alteplase in the CLEAR III Trial. Neurocrit Care. 2019 Apr;30(2):380-386. doi: 10.1007/s12028-018-0610-0. PubMed PMID: 30251074; PubMed Central PMCID: PMC6420835.
thalamic_hemorrhage.txt · Last modified: 2019/08/14 17:33 by administrador