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Thrombin receptor

Activation of a thrombin receptor, protease activated receptor 1 (PAR-1), induces angiogenesis, cell proliferation, and invasion in tumors.

There are three known thrombin receptors termed PAR1, PAR3 and PAR4.

These receptors are members of the 7 transmembrane g protein-coupled family of receptors, however, their method of activation is unique. Thrombin, a serine protease, binds to and cleaves the extracellular N-terminal domain of the receptor. A tethered ligand corresponding to the new N-terminus, SFLLRN, is then unmasked, binding to the second extracellular loop of the receptor and activating it.

thrombin_receptor.txt · Last modified: 2018/09/14 11:50 by administrador