Transcranial magnetic resonance guided focused ultrasound

Transcranial focused ultrasound (tFUS) at low intensities has been reported to directly evoke responses and reversibly inhibit function in the central nervous system. While some doubt has been cast on the ability of ultrasound to directly evoke neuronal responses, spatially-restricted transcranial ultrasound has demonstrated consistent, inhibitory effects

tFUS predominantly causes neuroinhibition and the most primary biophysical mechanism is the thermal effect of focused ultrasound 1).

Darrow DP, O'Brien P, Richner TJ, Netoff TI, Ebbini ES. Reversible neuroinhibition by focused ultrasound is mediated by a thermal mechanism. Brain Stimul. 2019 Jul 23. pii: S1935-861X(19)30299-2. doi: 10.1016/j.brs.2019.07.015. [Epub ahead of print] PubMed PMID: 31377096.
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