Blood transfusion, the introduction of blood directly into an individual’s blood circulation through a vein
Higher threshold is warranted only when the patient is clinically symptomatic.
For platelets, transfusion thresholds should be at least 50,000/mm(3) for patients without and 100,000/mm(3) for patients with evidence of hemorrhage. Reversal of antiplatelet therapy with platelet transfusion is advisable only in patients with active bleeding. Tests for platelet function are helpful in determining an adequate platelet transfusion in these situations.
Fresh frozen plasma transfusion for correction of warfarin-induced coagulopathy is also advisable in patients with active bleeding. If available, activated factor VII can be used in refractory cases. Prothrombin complex concentrates are also another alternative in refractory situations. Transfusion goals for patients with evidence of hemorrhage should be an International Normalized Ratio of 1.3 or less 1).