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tumorigenesis

Tumorigenesis

Carcinogenesis or oncogenesis or tumorigenesis is literally the 'creation' of cancer. It is a process by which normal cells are transformed into cancer cells. It is characterized by a progression of changes at the cellular, genetic and epigenetic level that ultimately reprogram a cell to undergo uncontrolled cell division, thus forming a malignant mass.

Increasing evidence has suggested that microRNAs (miRNAs) are critical regulators of tumorigenesis 1).

The induction of epithelial mesenchymal transition (EMT) is important for carcinogenesis and cancer progression.

Survival of patients with glioma remains poor, which is largely attributed to active carcinogenesis.

The Hippo signaling pathway plays a crucial role in suppressing tumorigenesis.

1)
Li Q, Zhou L, Wang M, Wang N, Li C, Wang J, Qi L. MicroRNA-613 impedes the proliferation and invasion of glioma cells by targeting cyclin-dependent kinase 14. Biomed Pharmacother. 2017 Dec 28;98:636-642. doi: 10.1016/j.biopha.2017.12.044. [Epub ahead of print] PubMed PMID: 29289838.
tumorigenesis.txt · Last modified: 2018/01/01 19:50 by administrador