Carcinogenesis or oncogenesis or tumorigenesis is literally the 'creation' of cancer. It is a process by which normal cells are transformed into cancer cells. It is characterized by a progression of changes at the cellular, genetic and epigenetic level that ultimately reprogram a cell to undergo uncontrolled cell division, thus forming a malignant mass.
Survival of patients with glioma remains poor, which is largely attributed to active carcinogenesis.
The Hippo signaling pathway plays a crucial role in suppressing tumorigenesis.