University Hospital Regensburg

Klinik und Poliklinik für Neurochirurgie Klinikum der Universität Regensburg Franz-Josef-Strauß-Allee 11 93053 Regensburg www.uni-regensburg.de

Prof. Dr. med. Alexander T. BRAWANSKI Direktor Tel.: 0941/9449001 Fax: 0941/9449002 alexander.brawanski@klinik.uni-regensburg.de

Zech N, Seemann M, Seyfried TF, Lange M, Schlaier J, Hansen E. Deep Brain Stimulation Surgery without Sedation. Stereotact Funct Neurosurg. 2018 Dec 5:1-9. doi: 10.1159/000494803. [Epub ahead of print] PubMed PMID: 30517938.

2: Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, Anugu P, Wong Q, Malik R, Rauramaa R, Burkhardt R, Hardy R, Schmidt R, de Mutsert R, Morris RW, Strawbridge RJ, Wannamethee SG, Hägg S, Shah S, McLachlan S, Trompet S, Seshadri S, Kurl S, Heckbert SR, Ring S, Harris TB, Lehtimäki T, Galesloot TE, Shah T, de Faire U, Plagnol V, Rosamond WD, Post W, Zhu X, Zhang X, Guo X, Saba Y; MEGASTROKE Consortium, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytikäinen LP, Loeffler M, Evans MK, Debette S, Humphries SE, Völker U, Gudnason V, Hingorani AD, Björkegren JLM, Casas JP, O'Donnell CJ. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun. 2018 Dec 3;9(1):5141. doi: 10.1038/s41467-018-07340-5. PubMed PMID: 30510157.

3: Kreuzer PM, Downar J, de Ridder D, Schwarzbach J, Schecklmann M, Langguth B. A Comprehensive Review of Dorsomedial Prefrontal Cortex rTMS Utilizing a Double Cone Coil. Neuromodulation. 2018 Nov 8. doi: 10.1111/ner.12874. [Epub ahead of print] Review. PubMed PMID: 30411429.

4: Blazquez R, Wlochowitz D, Wolff A, Seitz S, Wachter A, Perera-Bel J, Bleckmann A, Beißbarth T, Salinas G, Riemenschneider MJ, Proescholdt M, Evert M, Utpatel K, Siam L, Schatlo B, Balkenhol M, Stadelmann C, Schildhaus HU, Korf U, Reinz E, Wiemann S, Vollmer E, Schulz M, Ritter U, Hanisch UK, Pukrop T. PI3K: A master regulator of brain metastasis-promoting macrophages/microglia. Glia. 2018 Nov;66(11):2438-2455. doi: 10.1002/glia.23485. Epub 2018 Oct 25. PubMed PMID: 30357946.

5: Schackel T, Kumar P, Günther M, Liu S, Brunner M, Sandner B, Puttagunta R, Mueller R, Weidner N, Blesch A. PEPTIDES AND ASTROGLIA IMPROVE THE REGENERATIVE CAPACITY OF ALGINATE GELS IN THE INJURED SPINAL CORD. Tissue Eng Part A. 2018 Oct 23. doi: 10.1089/ten.TEA.2018.0082. [Epub ahead of print] PubMed PMID: 30351234.

6: Megele R, Riemenschneider MJ, Dodoo-Schittko F, Feyrer M, Kleindienst A. Intra-tumoral treatment with oxygen-ozone in glioblastoma: A systematic literature search and results of a case series. Oncol Lett. 2018 Nov;16(5):5813-5822. doi: 10.3892/ol.2018.9397. Epub 2018 Sep 5. PubMed PMID: 30344733; PubMed Central PMCID: PMC6176341.

7: Andreiuolo F, Varlet P, Tauziède-Espariat A, Jünger ST, Dörner E, Dreschmann V, Kuchelmeister K, Waha A, Haberler C, Slavc I, Corbacioglu S, Riemenschneider MJ, Leipold A, Rüdiger T, Körholz D, Acker T, Russo A, Faber J, Sommer C, Armbrust S, Rose M, Erdlenbruch B, Hans VH, Bernbeck B, Schneider D, Lorenzen J, Ebinger M, Handgretinger R, Neumann M, van Buiren M, Prinz M, Roganovic J, Jakovcevic A, Park SH, Grill J, Puget S, Messing-Jünger M, Reinhard H, Bergmann M, Hattingen E, Pietsch T. Childhood supratentorial ependymomas with YAP1-MAMLD1 fusion: an entity with characteristic clinical, radiological, cytogenetic and histopathological features. Brain Pathol. 2018 Sep 23. doi: 10.1111/bpa.12659. [Epub ahead of print] PubMed PMID: 30246434.

8: Unterrainer M, Fleischmann DF, Diekmann C, Vomacka L, Lindner S, Vettermann F, Brendel M, Wenter V, Ertl-Wagner B, Herms J, Wetzel C, Rupprecht R, Tonn JC, Belka C, Bartenstein P, Niyazi M, Albert NL. Comparison of (18)F-GE-180 and dynamic (18)F-FET PET in high grade glioma: a double-tracer pilot study. Eur J Nucl Med Mol Imaging. 2018 Sep 22. doi: 10.1007/s00259-018-4166-1. [Epub ahead of print] PubMed PMID: 30244386.

9: Berg P, Voß S, Saalfeld S, Janiga G, Bergersen AW, Valen-Sendstad K, Bruening J, Goubergrits L, Spuler A, Cancelliere NM, Steinman DA, Pereira VM, Chiu TL, Tsang ACO, Chung BJ, Cebral JR, Cito S, Pallarès J, Copelli G, Csippa B, Paál G, Fujimura S, Takao H, Hodis S, Hille G, Karmonik C, Elias S, Kellermann K, Khan MO, Marsden AL, Morales HG, Piskin S, Finol EA, Pravdivtseva M, Rajabzadeh-Oghaz H, Paliwal N, Meng H, Seshadhri S, Howard M, Shojima M, Sugiyama SI, Niizuma K, Sindeev S, Frolov S, Wagner T, Brawanski A, Qian Y, Wu YA, Carlson KD, Dragomir-Daescu D, Beuing O. Multiple Aneurysms AnaTomy CHallenge 2018 (MATCH): Phase I: Segmentation. Cardiovasc Eng Technol. 2018 Sep 6. doi: 10.1007/s13239-018-00376-0. [Epub ahead of print] PubMed PMID: 30191538.

10: Faltermeier R, Proescholdt MA, Wolf S, Bele S, Brawanski A. A Patient-Independent Significance Test by Means of False-Positive Rates in Selected Correlation Analysis of Brain Multimodal Monitoring Data. Comput Math Methods Med. 2018 Aug 8;2018:6821893. doi: 10.1155/2018/6821893. eCollection 2018. PubMed PMID: 30159004; PubMed Central PMCID: PMC6109537.

11: Wagner A, Schebesch KM, Zeman F, Isenmann S, Steinbrecher A, Kapapa T, Baldaranov D, Backhaus R, Schlachetzki F. Primary cCT Imaging Based Clinico-Neurological Assessment-Calling for Addition of Telestroke Video Consultation in Patients With Intracerebral Hemorrhage. Front Neurol. 2018 Jul 26;9:607. doi: 10.3389/fneur.2018.00607. eCollection 2018. PubMed PMID: 30093878; PubMed Central PMCID: PMC6071543.

12: Seliger C, Luber C, Gerken M, Schaertl J, Proescholdt M, Riemenschneider MJ, Meier CR, Bogdahn U, Leitzmann MF, Klinkhammer-Schalke M, Hau P. Use of metformin and survival of patients with high-grade glioma. Int J Cancer. 2018 Aug 9. doi: 10.1002/ijc.31783. [Epub ahead of print] PubMed PMID: 30091464.

Schebesch KM, Brawanski A, Doenitz C, Rosengarth K, Proescholdt M, Riemenschneider MJ, Grosse J, Hellwig D, Höhne J. Fluorescence-guidance in non-Gadolinium enhancing, but FET-PET positive gliomas. Clin Neurol Neurosurg. 2018 Jul 19;172:177-182. doi: 10.1016/j.clineuro.2018.07.011. [Epub ahead of print] PubMed PMID: 30032095.

Acerbi F, Restelli F, De Laurentis C, Falco J, Cavallo C, Broggi M, Höhne J, Schebesch KM, Schiariti M, Ferroli P. Fluorescent tracers in neurosurgical procedures: an European survey. J Neurosurg Sci. 2018 Jul 17. doi: 10.23736/S0390-5616.18.04494-6. [Epub ahead of print] PubMed PMID: 30014688.

Brawanski K, Brockhoff G, Hau P, Vollmann-Zwerenz A, Freyschlag C, Lohmeier A, Riemenschneider MJ, Thomé C, Brawanski A, Proescholdt MA. Efficacy of D,L-methadone in the treatment of glioblastoma in vitro. CNS Oncol. 2018 Jun 19. doi: 10.2217/cns-2018-0006. [Epub ahead of print] PubMed PMID: 29916277.

4: Schaub C, Kebir S, Junold N, Hattingen E, Schäfer N, Steinbach JP, Weyerbrock A, Hau P, Goldbrunner R, Niessen M, Mack F, Stuplich M, Tzaridis T, Bähr O, Kortmann RD, Schlegel U, Schmidt-Graf F, Rohde V, Braun C, Hänel M, Sabel M, Gerlach R, Krex D, Belka C, Vatter H, Proescholdt M, Herrlinger U, Glas M. Tumor growth patterns of MGMT-non-methylated glioblastoma in the randomized GLARIUS trial. J Cancer Res Clin Oncol. 2018 Aug;144(8):1581-1589. doi: 10.1007/s00432-018-2671-z. Epub 2018 May 28. PubMed PMID: 29808316.

5: Schulze M, Hutterer M, Sabo A, Hoja S, Lorenz J, Rothhammer-Hampl T, Herold-Mende C, Floßbach L, Monoranu C, Riemenschneider MJ. Chronophin regulates active vitamin B6 levels and transcriptomic features of glioblastoma cell lines cultured under non-adherent, serum-free conditions. BMC Cancer. 2018 May 3;18(1):524. doi: 10.1186/s12885-018-4440-4. PubMed PMID: 29724193; PubMed Central PMCID: PMC5934884.

6: Acerbi F, de Laurentis C, Broggi M, Kiris T, Schebesch KM. In Reply to the Letter to the Editor Regarding ““Fluorescein-Guided Resection of Intramedullary Spinal Cord Tumors: Results from a Preliminary, Multicentric, Retrospective Study”. World Neurosurg. 2018 May;113:389. doi: 10.1016/j.wneu.2018.02.086. PubMed PMID: 29702957.

7: Hebebrand J, Peters T, Schijven D, Hebebrand M, Grasemann C, Winkler TW, Heid IM, Antel J, Föcker M, Tegeler L, Brauner L, Adan RAH, Luykx JJ, Correll CU, König IR, Hinney A, Libuda L. The role of genetic variation of human metabolism for BMI, mental traits and mental disorders. Mol Metab. 2018 Jun;12:1-11. doi: 10.1016/j.molmet.2018.03.015. Epub 2018 Apr 3. PubMed PMID: 29673576; PubMed Central PMCID: PMC6001916.

8: Ljubimova JY, Braubach O, Patil R, Chiechi A, Tang J, Galstyan A, Shatalova ES, Kleinman MT, Black KL, Holler E. Coarse particulate matter (PM(2.5-10)) in Los Angeles Basin air induces expression of inflammation and cancer biomarkers in rat brains. Sci Rep. 2018 Apr 9;8(1):5708. doi: 10.1038/s41598-018-23885-3. PubMed PMID: 29632393; PubMed Central PMCID: PMC5890281.

9: Hohenberger C, Schmidt C, Höhne J, Brawanski A, Zeman F, Schebesch KM. Effect of surgical decompression of spinal metastases in acute treatment - Predictors of neurological outcome. J Clin Neurosci. 2018 Jun;52:74-79. doi: 10.1016/j.jocn.2018.03.031. Epub 2018 Apr 2. PubMed PMID: 29622504.

10: Nowacki A, Schlaier J, Debove I, Pollo C. Validation of diffusion tensor imaging tractography to visualize the dentatorubrothalamic tract for surgical planning. J Neurosurg. 2018 Mar 23:1-10. doi: 10.3171/2017.9.JNS171321. [Epub ahead of print] PubMed PMID: 29570012.

11: Dettling S, Stamova S, Warta R, Schnölzer M, Rapp C, Rathinasamy A, Reuss D, Pocha K, Roesch S, Jungk C, Warnken U, Eckstein V, Grabe N, Schramm C, Weigand MA, von Deimling A, Unterberg A, Beckhove P, Herold-Mende C. Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma. Clin Cancer Res. 2018 Jun 15;24(12):2951-2962. doi: 10.1158/1078-0432.CCR-17-1839. Epub 2018 Mar 21. PubMed PMID: 29563135.

12: Reinert C, Rathberger K, Klinkhammer-Schalke M, Kölbl O, Proescholdt M, Riemenschneider MJ, Schuierer G, Hutterer M, Gerken M, Hau P. Information needs and requirements in patients with brain tumours and their relatives. J Neurooncol. 2018 Jun;138(2):407-415. doi: 10.1007/s11060-018-2811-y. Epub 2018 Mar 7. PubMed PMID: 29516343.

13: Sidhu PS, Cantisani V, Dietrich CF, Gilja OH, Saftoiu A, Bartels E, Bertolotto M, Calliada F, Clevert DA, Cosgrove D, Deganello A, D'Onofrio M, Drudi FM, Freeman S, Harvey C, Jenssen C, Jung EM, Klauser AS, Lassau N, Meloni MF, Leen E, Nicolau C, Nolsoe C, Piscaglia F, Prada F, Prosch H, Radzina M, Savelli L, Weskott HP, Wijkstra H. The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Short Version). Ultraschall Med. 2018 Apr;39(2):154-180. doi: 10.1055/s-0044-101254. Epub 2018 Mar 6. PubMed PMID: 29510440.

14: Sidhu PS, Cantisani V, Dietrich CF, Gilja OH, Saftoiu A, Bartels E, Bertolotto M, Calliada F, Clevert DA, Cosgrove D, Deganello A, D'Onofrio M, Drudi FM, Freeman S, Harvey C, Jenssen C, Jung EM, Klauser AS, Lassau N, Meloni MF, Leen E, Nicolau C, Nolsoe C, Piscaglia F, Prada F, Prosch H, Radzina M, Savelli L, Weskott HP, Wijkstra H. The EFSUMB Guidelines and Recommendations for the Clinical Practice of Contrast-Enhanced Ultrasound (CEUS) in Non-Hepatic Applications: Update 2017 (Long Version). Ultraschall Med. 2018 Apr;39(2):e2-e44. doi: 10.1055/a-0586-1107. Epub 2018 Mar 6. PubMed PMID: 29510439.

15: Wendl CM, Eiglsperger J, Dendl LM, Brodoefel H, Schebesch KM, Stroszczynski C, Fellner C. Fat suppression in magnetic resonance imaging of the head and neck region: is the two-point DIXON technique superior to spectral fat suppression? Br J Radiol. 2018 May;91(1085):20170078. doi: 10.1259/bjr.20170078. Epub 2018 Feb 23. PubMed PMID: 29436841.

16: Shiban E, Lehmberg J, Hoffmann U, Thiel J, Probst T, Friedl M, Mühlberger A, Meyer B, Shiban Y. Peritraumatic distress fully mediates the relationship between posttraumatic stress symptoms preoperative and three months postoperative in patients undergoing spine surgery. Eur J Psychotraumatol. 2018 Jan 19;9(1):1423824. doi: 10.1080/20008198.2018.1423824. eCollection 2018. PubMed PMID: 29410774; PubMed Central PMCID: PMC5795762.

17: Bründl E, Schödel P, Bele S, Proescholdt M, Scheitzach J, Zeman F, Brawanski A, Schebesch KM. Treatment of Spontaneous Subarachnoid Hemorrhage and Self-Reported Neuropsychological Performance at 6 Months - Results of a Prospective Clinical Pilot Study on Good-Grade Patients. Turk Neurosurg. 2018;28(3):369-388. doi: 10.5137/1019-5149.JTN.21825-17.0. PubMed PMID: 29204979.

18: Schäfer N, Proescholdt M, Steinbach JP, Weyerbrock A, Hau P, Grauer O, Goldbrunner R, Friedrich F, Rohde V, Ringel F, Schlegel U, Sabel M, Ronellenfitsch MW, Uhl M, Grau S, Hänel M, Schnell O, Krex D, Vajkoczy P, Tabatabai G, Mack F, Schaub C, Tzaridis T, Nießen M, Kebir S, Leutgeb B, Urbach H, Belka C, Stummer W, Glas M, Herrlinger U. Quality of life in the GLARIUS trial randomizing bevacizumab/irinotecan versus temozolomide in newly diagnosed, MGMT-nonmethylated glioblastoma. Neuro Oncol. 2018 Jun 18;20(7):975-985. doi: 10.1093/neuonc/nox204. PubMed PMID: 29121274; PubMed Central PMCID: PMC6007398.

19: Anthofer J, Herbst A, Janzen A, Lange M, Brawanski A, Schlaier J. Deep brain stimulation: custom-made silicone-coated pulse-generator implantation after allergic reaction to generator compounds. Acta Neurochir (Wien). 2018 Feb;160(2):385-387. doi: 10.1007/s00701-017-3373-z. Epub 2017 Nov 7. PubMed PMID: 29116383.

20: Acerbi F, Broggi M, Schebesch KM, Höhne J, Cavallo C, De Laurentis C, Eoli M, Anghileri E, Servida M, Boffano C, Pollo B, Schiariti M, Visintini S, Montomoli C, Bosio L, La Corte E, Broggi G, Brawanski A, Ferroli P. Fluorescein-Guided Surgery for Resection of High-Grade Gliomas: A Multicentric Prospective Phase II Study (FLUOGLIO). Clin Cancer Res. 2018 Jan 1;24(1):52-61. doi: 10.1158/1078-0432.CCR-17-1184. Epub 2017 Oct 10. PubMed PMID: 29018053.

21: Beier D, Proescholdt M, Reinert C, Pietsch T, Jones DTW, Pfister SM, Hattingen E, Seidel C, Dirven L, Luerding R, Reijneveld J, Warmuth-Metz M, Bonsanto M, Bremer M, Combs SE, Rieken S, Herrlinger U, Kuntze H, Mayer-Steinacker R, Moskopp D, Schneider T, Beringer A, Schlegel U, Stummer W, Welker H, Weyerbrock A, Paulsen F, Rutkowski S, Weller M, Wick W, Kortmann RD, Bogdahn U, Hau P. Multicenter pilot study of radiochemotherapy as first-line treatment for adults with medulloblastoma (NOA-07). Neuro Oncol. 2018 Feb 19;20(3):400-410. doi: 10.1093/neuonc/nox155. PubMed PMID: 29016837; PubMed Central PMCID: PMC5817955.

22: Höhne J, Werzmirzowsky K, Ott C, Hohenberger C, Hassanin BG, Brawanski A, Schebesch KM. Outcomes of Cranioplasty with Preformed Titanium versus Freehand Molded Polymethylmethacrylate Implants. J Neurol Surg A Cent Eur Neurosurg. 2018 May;79(3):200-205. doi: 10.1055/s-0037-1604362. Epub 2017 Aug 11. PubMed PMID: 28800664.

23: Kieninger M, Flessa J, Lindenberg N, Bele S, Redel A, Schneiker A, Schuierer G, Wendl C, Graf B, Silbereisen V. Side Effects of Long-Term Continuous Intra-arterial Nimodipine Infusion in Patients with Severe Refractory Cerebral Vasospasm after Subarachnoid Hemorrhage. Neurocrit Care. 2018 Feb;28(1):65-76. doi: 10.1007/s12028-017-0428-1. PubMed PMID: 28685393.

24: Höhne J, Schebesch KM, Ott C, Brawanski A, Lange M. The risk of hypotension and seizures in patients receiving prophylactic anti-epileptic drugs for supratentorial craniotomy. J Neurosurg Sci. 2018 Aug;62(4):418-422. doi: 10.23736/S0390-5616.16.03826-1. Epub 2016 Nov 17. PubMed PMID: 27854111.

Leidgens V, Proske J, Rauer L, Moeckel S, Renner K, Bogdahn U, Riemenschneider MJ, Proescholdt M, Vollmann-Zwerenz A, Hau P, Seliger C. Stattic and metformin inhibit brain tumor initiating cells by reducing STAT3-phosphorylation. Oncotarget. 2016 Dec 24. doi: 10.18632/oncotarget.14159. [Epub ahead of print] PubMed PMID: 28030813.