Unruptured intracranial aneurysm (UIA)

Around 3% of the adult global population has unruptured intracranial aneurysms (UIAs) 1)

It is clear that more incidental intracranial aneurysms will be encountered in the future and advancing technology can be expected to demonstrate them with increasing regularity.

The prevalence of Unruptured intracranial aneurysm (UIAs) in first-degree relatives of patients with aSAH in the Hong Kong Chinese population was lower than that in Caucasians. At the same time, most of the UIAs detected in a study were small (85.7% were < 5 mm, vs 66% in a meta-analysis). With a similar incidence of aSAH in Hong Kong (7.5 per 100,000 person-years) as compared with data cited in the literature, the hypothesis that UIA rupture risk size threshold is different in Chinese patients should be further investigated 2).

Higher in patients with autosomal dominant polycystic kidney disease (ADPKD) or a positive family history of intracranial aneurysm or subarachnoid haemorrhage than in people without comorbidity.

In Finland and Japan, the higher incidence of subarachnoid haemorrhage is not explained by a higher prevalence of UIAs, implicating higher risks of rupture 3).

During 1995 to 2004, a period of increasing neuroimaging utilization, Gabriel et al., did not observe an increased rate of detection of unruptured brain arteriovenous malformation (BAVM), despite increased detection of unruptured intracranial aneurysm (IA)s 4).

A analysis identified differentially expressed genes and miRNAs in unruptured human cerebral aneurysms, suggesting the possibility of a role for miRNAs in aneurysm formation 5)

Most unruptured intracranial aneurysms don’t have symptoms. “Most of these patients are found incidentally, when they get an MRI scan or computed tomography angiography scan for something unrelated.

Vlak MH, Rinkel GJ, Greebe P, Algra A. Risk of rupture of an intracranial aneurysm based on patient characteristics: a case–control study. Stroke. 2013;44(5):1256–9.
Chan DY, Abrigo JM, Cheung TC, Siu DY, Poon WS, Ahuja AT, Wong GK. Screening for intracranial aneurysms? Prevalence of unruptured intracranial aneurysms in Hong Kong Chinese. J Neurosurg. 2015 Oct 16:1-5. [Epub ahead of print] PubMed PMID: 26473778.
Vlak MH, Algra A, Brandenburg R, Rinkel GJ. Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis. Lancet Neurol. 2011 Jul;10(7):626-36. doi: 10.1016/S1474-4422(11)70109-0. Review. PubMed PMID: 21641282.
Gabriel RA, Kim H, Sidney S, McCulloch CE, Singh V, Johnston SC, Ko NU, Achrol AS, Zaroff JG, Young WL. Ten-year detection rate of brain arteriovenous malformations in a large, multiethnic, defined population. Stroke. 2010 Jan;41(1):21-6. doi: 10.1161/STROKEAHA.109.566018. Epub 2009 Nov 19. PubMed PMID: 19926839; PubMed Central PMCID: PMC2847493.
Bekelis K, Kerley-Hamilton JS, Teegarden A, Tomlinson CR, Kuintzle R, Simmons N, Singer RJ, Roberts DW, Kellis M, Hendrix DA. MicroRNA and gene expression changes in unruptured human cerebral aneurysms. J Neurosurg. 2016 Dec;125(6):1390-1399. PubMed PMID: 26918470; PubMed Central PMCID: PMC5001931.
  • unruptured_intracranial_aneurysm.txt
  • Last modified: 2023/03/20 13:19
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