Data suggest that use of vancomycin as prophylactic agent for cerebrospinal fluid shunt placement reduces the rate of shunt infections in the context of high prevalence of Methicillin resistant Staphylococcus aureus. 1).
The local application of powdered vancomycin was not associated with a significant difference in the rate of deep surgical site infection SSI after spinal deformity surgery, and other treatment modalities are necessary to limit infection for this high-risk group. This study is in contrary to prior studies, which have reported a decrease in SSI with vancomycin powder.Level of Evidence: 2 2)
Dombrowski et al. found a high rate of treatment failure in an urban population among patients who completed recommended therapy, largely with vancomycin alone. Failure in osteomyelitis was particularly common. High quality comparative studies of antibiotic regimens for MRSA infections, particularly osteomyelitis, are needed 3).
see Vancomycin powder.