vasogenic_edema

This edema is due to blood brain barrier (BBB) disruption resulting in extracellular water accumulation.

Animal and clinical studies have identified MMP-9 overexpression as a key factor responsible for the development of vasogenic edema, and deletion of Matrix metalloproteinase 9 (MMP-9) is correlated with significantly less brain edema and better neurological recovery in SAH mice models 1).


1)
Egashira Y, Hua Y, Keep RF, Xi G. Acute white matter injury after experimental subarachnoid hemorrhage: potential role of lipocalin 2. Stroke. 2014;45(7):2141–2143.
  • vasogenic_edema.txt
  • Last modified: 2018/12/19 05:57
  • by administrador