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Wiki History in Medicine


Wikipedia concept, which has developed as a result of the open-source software model using free (wiki) software ( The essential features are a revision control system, unrestricted editing of articles on the wiki by any registered member, unrestricted membership of the wiki, and the ability to fork articles (or see current versions at the same time). In addition, no copies are deleted and the newer versions of an article comprise the original article with all additions made cumulatively. 1).


The Medical Informatics communities should consider a more systematic use of these techniques for disseminating knowledge about the specialty for the public as well as for internal and educational purposes 2).

Maier et al. developed WikiGene, a Wiki-based curation tool that allows revision of the data by expert users over the Internet. LitMiner ( and WikiGene ( can be used unrestricted with any Internet browser 3).

These tools enable the team members to share knowledge simply and quickly-the collective knowledge base of the group can be efficiently managed and navigated 4).

BioLingua is an interactive, web-based programming environment that enables biologists to analyze biological systems by combining knowledge and data through direct end-user programming 5).

Do your students wiki? 6).

Wiki's wild world 7).

Internet encyclopaedias go head to head 8).


The server ( provides the electron crystallography community with a central information exchange platform, which is structured in blog and Wiki form, allowing visitors to add comments or discussions. It currently offers a detailed step-by-step introduction to image processing with the MRC software program. The server is also a repository for the 2dx software package, a user-friendly image processing system for 2D membrane protein crystals 9).

The gene finding server is accessible via The server software is available with the GenDB genome annotation system (version 2.2.1 onwards) under the GNU general public license. The software can be downloaded from More information on installing GenDB and REGANOR and the system requirements can be found on the GenDB project page 10).

Wiki and other ways to share learning online 11).

Gene and protein nomenclature in public databases 12).

Wiki ware could harness the Internet for science 13).

Gene-function wiki would let biologists pool worldwide resources 14).


Desai et al. described the pilot use of an enterprise wiki solution to facilitate group communication, secure file sharing, and collaborative writing within a pediatric hospital and research center. We discuss the choice of software, examples of use, and initial user feedback. We conclude that a wiki is a low-cost and high-yield approach to enhance research collaboration 15).

Catalyzing chemical bonding–the WIKI way 16).

TABASCO: A single molecule, base-pair resolved gene expression simulator 17).

Mass spectrometry and Web 2.0 18)

Stochastic simulation GUI for biochemical networks 19).

BioPP: a tool for web-publication of biological networks 20).

Globus MEDICUS - federation of DICOM medical imaging devices into healthcare Grids 21).

Other riffs on cooperation are already showing how well a wiki could work 22).

Key biology databases go wiki 23).

Legal pathways for cross-border research: building a legal platform for biomedical academia 24).

Genome re-annotation: a wiki solution? 25).

SNP2NMD: a database of human single nucleotide polymorphisms causing nonsense-mediated mRNA decay 26).


An explorative learning approach to teaching clinical anatomy using student generated content 27).

Balancing entrepreneurship and business practices for e-collaboration: responsible information sharing in academic research 28).

The RNA WikiProject: community annotation of RNA families 29).

Using a wiki to meet graduate nursing education competencies in collaboration and community health 30).

Putting wikis to work in libraries 31).

Search extension transforms Wiki into a relational system: a case for flavonoid metabolite database 32).

Big data: open-source format needed to aid wiki collaboration 33).

A new, dynamic resource for both students and teachers of family medicine: the Family Medicine Research wiki at FMDRL 34).

TRANSDAB Wiki database 35).

A wiki for the life sciences where authorship matters 36).

BioJava: an open-source framework for bioinformatics 37).

The medical matters wiki: building a library Web site 2.0 38). case-based orthopaedic Wiki project in China 39).

Hodis E, Prilusky J, Martz E, Silman I, Moult J, Sussman JL. Proteopedia - a scientific 'wiki' bridging the rift between three-dimensional structure and function of biomacromolecules. Genome Biol. 2008;9(8):R121. doi: 10.1186/gb-2008-9-8-r121. Epub 2008 Aug 3. PubMed PMID: 18673581; PubMed Central PMCID: PMC2575511.

Huss JW 3rd, Orozco C, Goodale J, Wu C, Batalov S, Vickers TJ, Valafar F, Su AI. A gene wiki for community annotation of gene function. PLoS Biol. 2008 Jul 8;6(7):e175. doi: 10.1371/journal.pbio.0060175. PubMed PMID: 18613750; PubMed Central PMCID: PMC2443188.

Pickard WF. Modelling the swelling assay for aquaporin expression. J Math Biol. 2008 Dec;57(6):883-903. doi: 10.1007/s00285-008-0196-9. Epub 2008 Jun 28. PubMed PMID: 18587542.

Dinov ID, Christou N, Sanchez J. Central Limit Theorem: New SOCR Applet and Demonstration Activity. J Stat Educ. 2008 Jul 1;16(2):1-15. PubMed PMID: 21833159; PubMed Central PMCID: PMC3152447.

Stokes TH, Torrance JT, Li H, Wang MD. ArrayWiki: an enabling technology for sharing public microarray data repositories and meta-analyses. BMC Bioinformatics. 2008 May 28;9 Suppl 6:S18. doi: 10.1186/1471-2105-9-S6-S18. PubMed PMID: 18541053; PubMed Central PMCID: PMC2423441.

Pawlicki S, Le Béchec A, Delamarche C. AMYPdb: a database dedicated to amyloid precursor proteins. BMC Bioinformatics. 2008 Jun 10;9:273. doi: 10.1186/1471-2105-9-273. PubMed PMID: 18544157; PubMed Central PMCID: PMC2442844.

Mons B, Ashburner M, Chichester C, van Mulligen E, Weeber M, den Dunnen J, van Ommen GJ, Musen M, Cockerill M, Hermjakob H, Mons A, Packer A, Pacheco R, Lewis S, Berkeley A, Melton W, Barris N, Wales J, Meijssen G, Moeller E, Roes PJ, Borner K, Bairoch A. Calling on a million minds for community annotation in WikiProteins. Genome Biol. 2008;9(5):R89. doi: 10.1186/gb-2008-9-5-r89. Epub 2008 May 28. PubMed PMID: 18507872; PubMed Central PMCID: PMC2441475.

Wang X. miRDB: a microRNA target prediction and functional annotation database with a wiki interface. RNA. 2008 Jun;14(6):1012-7. doi: 10.1261/rna.965408. Epub 2008 Apr 21. PubMed PMID: 18426918; PubMed Central PMCID: PMC2390791.

Kabachinski J. The word for quick is wiki-wiki. Biomed Instrum Technol. 2008 Mar-Apr;42(2):119-21. doi: 10.2345/0899-8205(2008)42[119:TWFQIW]2.0.CO;2. PubMed PMID: 18397129.

Harris ST, Zeng X. Using wiki in an online record documentation systems course. Perspect Health Inf Manag. 2008 Jan 30;5:1. PubMed PMID: 18311325; PubMed Central PMCID: PMC2242345.

Fung IC. Open access for the non-English-speaking world: overcoming the language barrier. Emerg Themes Epidemiol. 2008 Jan 4;5:1. doi: 10.1186/1742-7622-5-1. PubMed PMID: 18173854; PubMed Central PMCID: PMC2268932.

Karolchik D, Kuhn RM, Baertsch R, Barber GP, Clawson H, Diekhans M, Giardine B, Harte RA, Hinrichs AS, Hsu F, Kober KM, Miller W, Pedersen JS, Pohl A, Raney BJ, Rhead B, Rosenbloom KR, Smith KE, Stanke M, Thakkapallayil A, Trumbower H, Wang T, Zweig AS, Haussler D, Kent WJ. The UCSC Genome Browser Database: 2008 update. Nucleic Acids Res. 2008 Jan;36(Database issue):D773-9. Epub 2007 Dec 17. PubMed PMID: 18086701; PubMed Central PMCID: PMC2238835.


Flórez LA, Roppel SF, Schmeisky AG, Lammers CR, Stülke J. A community-curated consensual annotation that is continuously updated: the Bacillus subtilis centred wiki SubtiWiki. Database (Oxford). 2009;2009:bap012. Epub 2009 Sep 17. PubMed PMID: 20157485; PubMed Central PMCID: PMC2790307.

13: McCleary L, McGilton K, Boscart V, Oudshoorn A. Improving gerontology content in baccalaureate nursing education through knowledge transfer to nurse educators. Nurs Leadersh (Tor Ont). 2009;22(3):33-46. PubMed PMID: 20057265.

14: Lanning LC, Dadig BA. A strategy for incorporating palliative care and end-of-life instruction into physician assistant education. J Physician Assist Educ. 2010;21(4):41-6. PubMed PMID: 21366115.

15: Fang YH, Asthana P, Salinas C, Huang HM, Muzic RF Jr. Integrated software environment based on COMKAT for analyzing tracer pharmacokinetics with molecular imaging. J Nucl Med. 2010 Jan;51(1):77-84. doi: 10.2967/jnumed.109.064824. Epub 2009 Dec 15. PubMed PMID: 20008992; PubMed Central PMCID: PMC3500835.

16: Lammers CR, Flórez LA, Schmeisky AG, Roppel SF, Mäder U, Hamoen L, Stülke J. Connecting parts with processes: SubtiWiki and SubtiPathways integrate gene and pathway annotation for Bacillus subtilis. Microbiology. 2010 Mar;156(Pt 3):849-59. doi: 10.1099/mic.0.035790-0. Epub 2009 Dec 3. PubMed PMID: 19959575.

17: Marsico A, Scheubert K, Tuukkanen A, Henschel A, Winter C, Winnenburg R, Schroeder M. MeMotif: a database of linear motifs in alpha-helical transmembrane proteins. Nucleic Acids Res. 2010 Jan;38(Database issue):D181-9. doi: 10.1093/nar/gkp1042. Epub 2009 Nov 12. PubMed PMID: 19910368; PubMed Central PMCID: PMC2808916.

18: Rhead B, Karolchik D, Kuhn RM, Hinrichs AS, Zweig AS, Fujita PA, Diekhans M, Smith KE, Rosenbloom KR, Raney BJ, Pohl A, Pheasant M, Meyer LR, Learned K, Hsu F, Hillman-Jackson J, Harte RA, Giardine B, Dreszer TR, Clawson H, Barber GP, Haussler D, Kent WJ. The UCSC Genome Browser database: update 2010. Nucleic Acids Res. 2010 Jan;38(Database issue):D613-9. doi: 10.1093/nar/gkp939. Epub 2009 Nov 11. PubMed PMID: 19906737; PubMed Central PMCID: PMC2808870.

19: Jalali A, Mioduszewski M, Gauthier M, Varpio L. Wiki use and challenges in undergraduate medical education. Med Educ. 2009 Nov;43(11):1117. doi: 10.1111/j.1365-2923.2009.03480.x. PubMed PMID: 19874526.

20: Mattanovich D, Callewaert N, Rouzé P, Lin YC, Graf A, Redl A, Tiels P, Gasser B, De Schutter K. Open access to sequence: browsing the Pichia pastoris genome. Microb Cell Fact. 2009 Oct 16;8:53. doi: 10.1186/1475-2859-8-53. PubMed PMID: 19835590; PubMed Central PMCID: PMC2768684.

21: McKeon M. Harnessing the web information ecosystem with wiki-based visualization dashboards. IEEE Trans Vis Comput Graph. 2009 Nov-Dec;15(6):1081-8. doi: 10.1109/TVCG.2009.148. PubMed PMID: 19834175.

22: Wang XB, Wu LY, Wang YC, Deng NY. Prediction of palmitoylation sites using the composition of k-spaced amino acid pairs. Protein Eng Des Sel. 2009 Nov;22(11):707-12. doi: 10.1093/protein/gzp055. Epub 2009 Sep 25. PubMed PMID: 19783671.

23: Meyer F, Overbeek R, Rodriguez A. FIGfams: yet another set of protein families. Nucleic Acids Res. 2009 Nov;37(20):6643-54. doi: 10.1093/nar/gkp698. Epub 2009 Sep 17. PubMed PMID: 19762480; PubMed Central PMCID: PMC2777423.

24: Arakawa K, Oshita K, Tomita M. A web server for interactive and zoomable Chaos Game Representation images. Source Code Biol Med. 2009 Sep 17;4:6. doi: 10.1186/1751-0473-4-6. PubMed PMID: 19761591; PubMed Central PMCID: PMC2753581.

25: Manning JR, Hedley A, Mullins JJ, Dunbar DR. Automated seeding of specialised wiki knowledgebases with BioKb. BMC Bioinformatics. 2009 Sep 16;10:291. doi: 10.1186/1471-2105-10-291. PubMed PMID: 19758431; PubMed Central PMCID: PMC2753848.

26: Huss JW 3rd, Lindenbaum P, Martone M, Roberts D, Pizarro A, Valafar F, Hogenesch JB, Su AI. The Gene Wiki: community intelligence applied to human gene annotation. Nucleic Acids Res. 2010 Jan;38(Database issue):D633-9. doi: 10.1093/nar/gkp760. Epub 2009 Sep 15. PubMed PMID: 19755503; PubMed Central PMCID: PMC2808918.

27: Molander L, Gerstrand M, Rudén C. WikiPharma - a freely available, easily accessible, interactive and comprehensive database for environmental effect data for pharmaceuticals. Regul Toxicol Pharmacol. 2009 Dec;55(3):367-71. doi: 10.1016/j.yrtph.2009.08.009. Epub 2009 Aug 29. PubMed PMID: 19720105.

28: Kelder T, Pico AR, Hanspers K, van Iersel MP, Evelo C, Conklin BR. Mining biological pathways using WikiPathways web services. PLoS One. 2009 Jul 30;4(7):e6447. doi: 10.1371/journal.pone.0006447. PubMed PMID: 19649250; PubMed Central PMCID: PMC2714472.

29: Skinner ME, Uzilov AV, Stein LD, Mungall CJ, Holmes IH. JBrowse: a next-generation genome browser. Genome Res. 2009 Sep;19(9):1630-8. doi: 10.1101/gr.094607.109. Epub 2009 Jul 1. PubMed PMID: 19570905; PubMed Central PMCID: PMC2752129.

30: Nielsen FA. Lost in localization: a solution with neuroinformatics 2.0? Neuroimage. 2009 Oct 15;48(1):11-3. doi: 10.1016/j.neuroimage.2009.05.073. Epub 2009 Jun 2. PubMed PMID: 19497377.

31: Joppa LN. Journal club. An ecologist calls for a citizen-science 'Wiki'. Nature. 2009 Jun 4;459(7247):619. doi: 10.1038/459619e. PubMed PMID: 19494869.

32: Phair L. The development of the West Sussex institutional care neglect risk assessment tool: a reflective analysis using Mezirow's transformative learning framework. Int J Older People Nurs. 2009 Jun;4(2):132-41. doi: 10.1111/j.1748-3743.2009.00166.x. PubMed PMID: 20925813.

33: Razumovitch J, de França K, Kehl F, Wiki M, Meier W, Vebert C. Optimal hybridization efficiency upon immobilization of oligonucleotide double helices. J Phys Chem B. 2009 Jun 18;113(24):8383-90. doi: 10.1021/jp902383m. PubMed PMID: 19469563.

34: Hoehndorf R, Bacher J, Backhaus M, Gregorio SE Jr, Loebe F, Prüfer K, Uciteli A, Visagie J, Herre H, Kelso J. BOWiki: an ontology-based wiki for annotation of data and integration of knowledge in biology. BMC Bioinformatics. 2009 May 6;10 Suppl 5:S5. doi: 10.1186/1471-2105-10-S5-S5. PubMed PMID: 19426462; PubMed Central PMCID: PMC2679405.

35: Hibbert DB, Minkkinen P, Faber NM, Wise BM. IUPAC project: a glossary of concepts and terms in chemometrics. Anal Chim Acta. 2009 May 29;642(1-2):3-5. doi: 10.1016/j.aca.2009.02.020. Epub 2009 Feb 21. PubMed PMID: 19427452.

36: Dubois JM. The biomedical ethics ontology proposal: excellent aims, questionable methods. J Empir Res Hum Res Ethics. 2009 Mar;4(1):59-62. doi: 10.1525/jer.2009.4.1.59. PubMed PMID: 19382878; PubMed Central PMCID: PMC2838195.

37: Kardong-Edgren SE, Oermann MH, Ha Y, Tennant MN, Snelson C, Hallmark E, Rogers N, Hurd D. Using a wiki in nursing education and research. Int J Nurs Educ Scholarsh. 2009;6:Article6. doi: 10.2202/1548-923X.1787. Epub 2009 Mar 8. PubMed PMID: 19341356.

38: Manthous CA. Why not physician-assisted death? Crit Care Med. 2009 Apr;37(4):1206-9. PubMed PMID: 19326573.

39: Lau AS. Implementation of an onto-wiki toolkit using web services to improve the efficiency and effectiveness of medical ontology co-authoring and analysis. Inform Health Soc Care. 2009 Jan;34(1):73-80. doi: 10.1080/17538150902779543. PubMed PMID: 19306201.

40: Friend S, Schadt E. Something wiki this way comes. Interview by Bryn Nelson. Nature. 2009 Mar 5;458(7234):13. doi: 10.1038/458013a. PubMed PMID: 19262635.

41: Dinov ID, Christou N, Gould R. Law of Large Numbers: the Theory, Applications and Technology-based Education. J Stat Educ. 2009 Mar;17(1):1-19. PubMed PMID: 21603584; PubMed Central PMCID: PMC3095954.

42: Chu A, Cui J, Dinov ID. SOCR Analyses - an Instructional Java Web-based Statistical Analysis Toolkit. J Online Learn Teach. 2009 Mar 1;5(1):1-18. PubMed PMID: 21546994; PubMed Central PMCID: PMC3086312.

43: Demczuk L, Gottschalk T, Littleford J. Introducing information literacy into anesthesia curricula. Can J Anaesth. 2009 Apr;56(4):327-35. doi: 10.1007/s12630-009-9063-4. Epub 2009 Feb 27. Review. PubMed PMID: 19247736.

44: Hannemann J, Poorter H, Usadel B, Bläsing OE, Finck A, Tardieu F, Atkin OK, Pons T, Stitt M, Gibon Y. Xeml Lab: a tool that supports the design of experiments at a graphical interface and generates computer-readable metadata files, which capture information about genotypes, growth conditions, environmental perturbations and sampling strategy. Plant Cell Environ. 2009 Sep;32(9):1185-200. doi: 10.1111/j.1365-3040.2009.01964.x. Epub 2009 Feb 19. PubMed PMID: 19236607.

45: Cobus L. Using blogs and wikis in a graduate public health course. Med Ref Serv Q. 2009 Spring;28(1):22-32. doi: 10.1080/02763860802615922. PubMed PMID: 19197741.

46: Meenan C, King A, Toland C, Daly M, Nagy P. Use of a wiki as a radiology departmental knowledge management system. J Digit Imaging. 2010 Apr;23(2):142-51. doi: 10.1007/s10278-009-9180-1. Epub 2009 Jan 30. PubMed PMID: 19184221; PubMed Central PMCID: PMC3043765.

47: Feltrin E, Campanaro S, Diehl AD, Ehler E, Faulkner G, Fordham J, Gardin C, Harris M, Hill D, Knoell R, Laveder P, Mittempergher L, Nori A, Reggiani C, Sorrentino V, Volpe P, Zara I, Valle G, Deegan J. Muscle Research and Gene Ontology: New standards for improved data integration. BMC Med Genomics. 2009 Jan 29;2:6. doi: 10.1186/1755-8794-2-6. PubMed PMID: 19178689; PubMed Central PMCID: PMC2657163.

48: Seebregts CJ, Mamlin BW, Biondich PG, Fraser HS, Wolfe BA, Jazayeri D, Allen C, Miranda J, Baker E, Musinguzi N, Kayiwa D, Fourie C, Lesh N, Kanter A, Yiannoutsos CT, Bailey C; OpenMRS Implementers Network. The OpenMRS Implementers Network. Int J Med Inform. 2009 Nov;78(11):711-20. doi: 10.1016/j.ijmedinf.2008.09.005. Epub 2009 Jan 20. PubMed PMID: 19157968.

49: Zhou F, Xu Y. RepPop: a database for repetitive elements in Populus trichocarpa. BMC Genomics. 2009 Jan 9;10:14. doi: 10.1186/1471-2164-10-14. PubMed PMID: 19134208; PubMed Central PMCID: PMC2645430.

50: Martz E. Proteopedia.Org: a scientific “Wiki” bridging the rift between 3D structure and function of biomacromolecules. Biopolymers. 2009;92(1):76-7. doi: 10.1002/bip.21126. PubMed PMID: 19117028.

51: Szpakowski S, McCusker J, Krauthammer M. Using semantic web technologies to annotate and align microarray designs. Cancer Inform. 2009 May 13;8:65-73. eCollection 2009. PubMed PMID: 24904201; PubMed Central PMCID: PMC4042255.

52: Mason F. Medi-wiki worries? Open Med. 2009;3(3):e122a. Epub 2009 Aug 13. PubMed PMID: 21603048; PubMed Central PMCID: PMC3090120.

53: He S, Nachimuthu SK, Shakib SC, Lau LM. Collaborative authoring of biomedical terminologies using a semantic Wiki. AMIA Annu Symp Proc. 2009 Nov 14;2009:234-8. PubMed PMID: 20351856; PubMed Central PMCID: PMC2815405.

54: Arita M. A pitfall of wiki solution for biological databases. Brief Bioinform. 2009 May;10(3):295-6. doi: 10.1093/bib/bbn053. Epub 2008 Dec 6. PubMed PMID: 19060305.

55: Mao F, Dam P, Chou J, Olman V, Xu Y. DOOR: a database for prokaryotic operons. Nucleic Acids Res. 2009 Jan;37(Database issue):D459-63. doi: 10.1093/nar/gkn757. Epub 2008 Nov 6. PubMed PMID: 18988623; PubMed Central PMCID: PMC2686520.

56: Fey P, Gaudet P, Curk T, Zupan B, Just EM, Basu S, Merchant SN, Bushmanova YA, Shaulsky G, Kibbe WA, Chisholm RL. dictyBase–a Dictyostelium bioinformatics resource update. Nucleic Acids Res. 2009 Jan;37(Database issue):D515-9. doi: 10.1093/nar/gkn844. Epub 2008 Oct 30. PubMed PMID: 18974179; PubMed Central PMCID: PMC2686522.

57: Wright A, Bates DW, Middleton B, Hongsermeier T, Kashyap V, Thomas SM, Sittig DF. Creating and sharing clinical decision support content with Web 2.0: Issues and examples. J Biomed Inform. 2009 Apr;42(2):334-46. doi: 10.1016/j.jbi.2008.09.003. Epub 2008 Oct 8. PubMed PMID: 18935982.

58: Lee CH, Teo C, Low AF. Fulminant dengue myocarditis masquerading as acute myocardial infarction. Int J Cardiol. 2009 Aug 21;136(3):e69-71. doi: 10.1016/j.ijcard.2008.05.023. Epub 2008 Aug 13. PubMed PMID: 18701172.

59: Csosz E, Meskó B, Fésüs L. Transdab wiki: the interactive transglutaminase substrate database on web 2.0 surface. Amino Acids. 2009 Apr;36(4):615-7. doi: 10.1007/s00726-008-0121-y. Epub 2008 Jul 2. Review. PubMed PMID: 18594947.


Warner JL, Smith J, Wright A. It's Time to Wikify Clinical Documentation: How Collaborative Authorship Can Reduce the Burden and Improve the Quality of the Electronic Health Record. Acad Med. 2019 May;94(5):645-650. doi: 10.1097/ACM.0000000000002613. PubMed PMID: 30681451.

Wiki is a web page whose content can be edited in real time using a web browser.

Wiki technology offers a number of potential benefits for administrators, students and instructors, including the ability to share information online, to construct knowledge together, to facilitate collaboration and to enable social learning and peer feedback.

Rasmussen et al. believed that with proper planning and instructional design, wiki technology can be usefully employed in medical education. Theuy intended to continue to study the impact of wiki technology in there own programme, and encouraged others to evaluate the application of wiki technology in other areas of medical education.

Cox SR. Technology to enhance in-class discussions and student participation at a multi-campus program. Curr Pharm Teach Learn. 2019 Jul;11(7):719-722. doi: 10.1016/j.cptl.2019.03.010. Epub 2019 Mar 23. PubMed PMID: 31227095.

Schmidt S, Mau W. [Development of a Rehab-Wiki for rehabilitation-Related Educational Materials Assigned to Competence-Based Learning Objectives]. Rehabilitation (Stuttg). 2019 Apr;58(2):128-135. doi: 10.1055/a-0847-7344. Epub 2019 Feb 22. German. PubMed PMID: 30795025.

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wiki.txt · Last modified: 2019/09/14 00:34 by administrador